COMPARISION OF INTRAVENOUS MIDAZOLAM/ KETAMINE WITH DEXMEDETOMIDINE-PROPOFOL COMBINATION FOR SEDOANALGESIA IN ENDOSCOPIC RETROGRADE CHOLANGIO PANCREATOGRAPHY( ERCP) PROCEDURES IN TERTIARY CARE HOSPITAL

Background:Endoscopic retrograde cholangiopancreatography (ERCP), often require sedation during the procedure. The most commonly used drugs for this purpose are midazolam and propofol, which as sedative hypnotic agents with minimal analgesic potential. Aims & objectives:Effects of Sedoanalgesia Midazolam/ ketamine long Dexmedetomidine nfusion Rescue propofol alliquotes regimes on hemodynamic respiratory variables& recovery profile in patients undergoing ERCP. Methods:In Retrospective observational study adult ASA grade l- lll were enrolled after taking inform consent from patient their relatives. Premedication was given form inj.Midazolam 0.02 mg/kg iv Group l,.inj 0.5 group ll. Inj.Dexmedetomidine ( bolus dose 1 μg/kg over 10 min) followed by 0.5μg/kg/hour maintenance both groups.intermittent Intravenous Propofol maintain BIS 70-80 groups. Amount procedure notified.. Hemodynamic variables, time adverse events monitored recorded. Results:The variables similar Total consumption significantly lower (205+/-80 mg vs.155+/-20 p < 0.001). period shorter ll (time to achieve Aldrete score 9 9.0 ±2.2 vs. , 6.2+/-1.1min 0.001).Adverse comparable between two Conclusion:Ketamine-Dexmedetomidine combination may be a safe useful alternative ERCP patients.